Immunotherapy in Ovarian Cancer

Create a thesis and an outline on Immunotherapy in Ovarian Cancer. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. The above four systems have adverse side effects, and the chances for the recurrence of the disease is very high. Immunotherapy does not have these adverse effects and is the most trusted one. The agents of immunotherapy are called as immunomodulators, with immunologic effectors such as MAbs, cytokines, and lymphocytes being used. (Liu et al. 2010). The immune system is stimulated to destroy or reject the tumor from the body. The types of immunotherapy practiced for cancer are Dendritic cell-based immunotherapy, Adoptive T-cell therapy with tumor-infiltrating lymphocytes, Vaccines, and Engineering T cells.A number of defective proteins are produced by the cancer cells if the immune system is not working properly in our body. Sometimes, a high concentration of cancer proteins is produced and these abnormalities lead to an immune response, and that affects the cancer cells and the infected tissue. (Stiff, Czerlanis and Drakes 2013). In many types of cancer, the immune system fails to identify and respond to the abnormalities, and the cancer cells are not attacked. Now the scientists are trying to find out a way to stimulate the immune system to recognize the cancer cells and destroy or inhibit the growth of cancer cells. During organ transplants, the patients receive some special drugs, to make the host accept the donor organs. In organ transplants, there are chances for acceptance and rejection of the donor organs. If the immune system identifies the differences in the cells of the transplanted organ, then the immune system will attack the host cells and the rejection rate will be very high and destructive to the patient. (Mantovani and Sica 2010). The presence of a single foreign gene in the transplant may make the own immune system to identify as a cancer cell and destroy it. Chemotherapy is used in combination with the organ transplant, but the survival rate is not high. Many drugs are being tried to improve the survival rate and the&nbsp.current study also uses drugs such as Folfirinox, gemcitabine, capecitabine, Nab-paclitaxel along with 5-FU chemoradiation and Aplgenpantucel – L Immunotherapy. (Mabuchi, Morishique and Kimura 2010). This is a Phase III study to assess the overall survival rate of pancreatic cancer patients with unresectable pancreatic cancer. (Clinical Trails 2014).

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